Org 27569

CAS NO

868273-06-7

Formula

C24H28ClN3O

Solubility

DMSO

Storage

at -20℃ 2 years

Weight

409.95

Biological Activity

Org 27569 is an allosteric modulator of CB1 cannabinoid receptor. It significantly increases the binding of CB1 receptor agonist [3H]-CP 55,940 (pKB = 5.67) and causes a significant decrease in specific binding of CB1 receptor inverse agonist SR141716A (Rimonabant; pKB = 5.95); in the reporter gene assay behaves as insurmountable CP 55,940 antagonist; pKB = 7.57 at CB1 receptors in mouse vas deferens. [1]

References

[1] Price MR et al. Mol Pharmacol. 2005 Nov;68(5):1484-95