ABT-737

CAS NO

852808-04-9

Formula

C42H45ClN6O5S2

Solubility

DMSO

Storage

at -20℃ 2 years

Weight

813.43

Biological Activity

ABT-737 is a pan-Bcl-2 inhibitor that has a wide range of single-agent activity against acute lymphoblastic leukemia (ALL) cell lines and xenografts. Increased expression of the Bcl-2 family of proteins in cancers has been associated with chemotherapy resistance,

References

[1] Addeo R et al. Cancer Biol Ther.2005 Jan;4(1):32-8