NVP-TAE684

CAS NO

761439-42-3

Formula

C30H40ClN7O3S

Solubility

DMSO

Storage

at -20℃ 2 years

Weight

614.2

Biological Activity

NVP-TAE684 is a highly potent and selective smallmolecule ALK inhibitor, which blocked the growth of ALCL-derived and ALK-dependent cell lines with IC50 values between 2 and 10 nM. NVP-TAE684 treatment resulted in a rapid and sustained inhibition of phosphorylation of NPM-ALK and its downstream effectors and subsequent induction of apoptosis and cell cycle arrest.In vivo, NVP-TAE684 suppressed lymphomagenesis in two independent models of ALK-positive ALCL and induced regression of established Karpas-299 lymphomas

References

Anna V. Galkin et al. Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):270-5